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業績（2018-2021）

Triterpenoid saponin from Panax ginseng increases the sensitivity of methicillin-resistant Staphylococcus aureus to β-lactam and
aminoglycoside antibiotics.

Tsutamoto S, Iwasaki Y, Shinohara A, Imamiya R, Samukawa K, Kawada-Matsuo M, Komatsuzawa H, Yamada Y, Mandokoro K, Iwao H, Horiguchi Y, Osada-Oka M.
Microbiol Spectr. 2024 Apr 22:e0322723.
doi:10.1128/spectrum.03227-23.

Recombinant mycobacterial DNA-binding protein 1 with post-translational modifications boosts IFN-gamma production from BCG-vaccinated individuals' blood cells in combination with CpG-DNA.

Ozeki Y, Yokoyama A, Nishiyama A, Yoshida Y, Ohara Y, Mashima T, Tomiyama C, Shaban AK, Takeishi A, Osada-Oka M, Yamaguchi T, Tateishi Y, Maeyama JI, Hakamata M, Moro H, Kikuchi T, Hayashi D, Suzuki F, Yamamoto T, Iho S, Katahira M, Yamamoto S, Matsumoto S. Natsui K, Tsuchiya A, Imamiya R, Osada-Oka M, Ishii Y, Koseki Y, Takeda N, Tomiyoshi K, Yamazaki F, Yoshida Y, Ohashi R, Ling Y, Ueda K, Moritoki N, Sato K, Nakajima T, Hasegawa Y, Okuda S, Shibata S, Terai S.
Sci Rep. 2024 Apr 21;14(1):9141.
doi: 10.1038/s41598-024-58836-8.

Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes.

Imamiya R, Shinohara A, Yakura D, Yamaguchi T, Ueda K, Oguro A, Minamiyama Y, Ichikawa H, Horiguchi Y, Osada-Oka M.
mBio. 2023 Feb 28;14(1):e0305122.
doi: 10.1128/mbio.03051-22.

Escherichia coli-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans.

Natsui K, Tsuchiya A, Imamiya R, Osada-Oka M, Ishii Y, Koseki Y, Takeda N, Tomiyoshi K, Yamazaki F, Yoshida Y, Ohashi R, Ling Y, Ueda K, Moritoki N, Sato K, Nakajima T, Hasegawa Y, Okuda S, Shibata S, Terai S.
Liver Int. 2023 Feb 8.
doi: 10.1111/liv.15539.

Interference of flagellar rotation up-regulates the expression of small RNA contributing to Bordetella pertussis infection.

Hiramatsu Y, Nishida T, Nugraha DK, Osada-Oka M, Nakane D, Imada K, Horiguchi Y.
Sci Adv. 2022 Dec 21;8(51):eade8971.
doi: 10.1126/sciadv.ade8971.

Effect of Porcine Colostral Exosomes on T Cells in the Peripheral Blood of Suckling Piglets

Miura H, Jimbo I, Oda M, Noguchi M, Kawasaki K, Osada-Oka M, Tsukahara T, Inoue R.
Animals (Basel). 2022 Aug 24;12(17):2172.
doi:10.3390/ani12172172.

Suppression of the doxorubicin response by hypoxia-inducible factor-1α is strictly dependent on oxygen concentrations under hypoxic condition

Osada-Oka M, Kuwamura H, Imamiya R, Kobayashi K, Minamiyama Y, Takahashi K, Tanaka M, Shiota M.
Eur J Pharmacol. 2022;920:174845.
doi:10.1016/j.ejphar.2022.174845.

Food additive-induced oxidative stress in rat male reproductive organs and hippocampus.

Minamiyama Y, Takemura S, Ichikawa H.
Archive Biochem Biophys 701, 2021.
doi.org/10.1016/j.abb.2021.108810<https://doi.org/10.1016/j.abb.2021.108810>

A Comparative study on egg yolk IgY production with different adjuvants and their inhibitory effects on Staphylococcus aureus.

Kubo N, Nishii M, Osada-Oka M, Hatta H.
J Poult Sci. 2021;58(3):192-199.
doi:10.2141/jpsa.0200062.

Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model.

Kabei K, Tateishi Y, Shiota M, Osada-Oka M, Nishide S, Uchida J, Nakatani T, Matsunaga S, Yamaguchi T, Tomita S, Miura K.
J Pharmacol Sci. 2020 Mar;142(3):93-100.
doi: 10.1016/j.jphs.2019.12.002.

Actions of various sweeteners on rat sperm.

Minamiyama Y, Kobayashi K, Noguchi Y, Takemura S, Ichikawa H. Glycative Stress Research 7(2): 132-141, 2020
doi:10.24659/gsr.7.2_132

TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.

Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N. J Hepatol. 2020 Oct;73(4):882-895. doi: 10.1016/j.jhep.2020.03.051.

Effects of Bisphenol A on Oxidative Stress in the Rat Brain.

Kobayashi K, Liu Y, Ichikawa H, Takemura S, Minamiyama Y. 2020 Antioxidants (Basel). 9.
doi: 10.3390/antiox9030240.

Adduct formation of delamanid with NAD in mycobacteria.

Hayashi M, Nishiyama A, Kitamoto R, Tateishi Y, Osada-Oka M, Nishiuchi Y, Kaboso SA, Chen X, Fujiwara M, Inoue Y, Kawano Y, Kawasaki M, Abe T, Sato T, Kaneko K, Itoh K, Matsumoto S, Matsumoto M. 2020 Antimicrob Agents Chemother. pii: AAC.01755-19.
doi: 10.1128/AAC.01755-19.

Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model.

Kabei K, Tateishi Y, Shiota M, Osada-Oka M, Nishide S, Uchida J, Nakatani T, Matsunaga S, Yamaguchi T, Tomita S, Miura K. 2020 J Pharmacol Sci. 142, 93-100.
doi: 10.1016/j.jphs.2019.12.002.

CD4(+) T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection.

Yamashita Y, Oe T, Kawakami K, Osada-Oka M, Ozeki Y, Terahara K, Yasuda I, Edwards T, Tanaka T, Tsunetsugu-Yokota Y, Matsumoto S, Ariyoshi K. 2019 Front Immunol. 10:2807.
doi: 10.3389/fimmu.2019.02807.

Bordet-Gengou agar medium supplemented with albumin-containing biologics for cultivation of bordetellae.

Hiramatsu Y, Osada-Oka M, Horiguchi Y. 2019 Microbiol Immunol. 63, 513-516.
doi: 10.1111/1348-0421.12742.

Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection.

Osada-Oka M, Goda N, Saiga H, Yamamoto M, Takeda K, Ozeki Y, Yamaguchi T, Soga T, Tateishi Y, Miura K, Okuzaki D, Kobayashi K, Matsumoto S. 2019 Int Immunol. 31, 781-793.
doi: 10.1093/intimm/dxz048.

Serum antibody profiles in individuals with latent Mycobacterium tuberculosis infection.

Maekura R, Kitada S, Osada-Oka M, Tateishi Y, Ozeki Y, Fujicawa T, Miki M, Jyunnko O, Mori M, Matsumoto S. 2019 Microbiol Immunol. 63, 130-138.
doi: 10.1111/1348-0421.12674.

Histidine and arginine modulate intestinal cell restitution via transforming growth factor-β1.

Matsui T, Ichikawa H, Fujita T, Takemura S, Takagi T, Osada-Oka M, Minamiyama Y. 2019 Eur J Pharmacol. 850, 35-42. doi: 10.1016/j.ejphar.2019.02.006.

A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-4.

Yamaguchi T, Watanabe A, Tanaka M, Shiota M, Osada-Oka M, Sano S, Yoshiyama M, Miura K, Kitajima S, Matsunaga S, Tomita S, Iwao H, Izumi Y. 2019 J Pharmacol Sci. 139, 112-119.
doi: 10.1016/j.jphs.2018.12.004.

High-density lipoprotein suppresses tumor necrosis factor alpha　production by mycobacteria-infected human macrophages.

Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka EA, Yamaguchi T, Osada-Oka M, Ono K, Oda T, Mwende F, Kaneko Y, Matsumoto M, Kaneko S, Ichinose Y, Njenga SM, Hamano S, Matsumoto S. 2018 Sci Rep. 30, 6736.
doi: 10.1038/s41598-018-24233-1.

S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats.

Takemura S, Azuma H, Osada-Oka M, Kubo S, Shibata T, Minamiyama Y.　 2018 Am J Physiol Gastrointest Liver Physiol. 314, G150-G163.
doi: 10.1152/ajpgi.00023.2017.

Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts.

Toda M, Mizuguchi S, Minamiyama Y, Yamamoto-Oka H, Aota T, Kubo S, Nishiyama N, Shibata T, Takemura S. 2018 J Clin Biochem Nutr. 63, 58-65.
doi: 10.3164/jcbn.17-111.

Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules.

Kabei K, Tateishi Y, Nozaki M, Tanaka M, Shiota M, Osada-Oka M, Nishide S, Uchida J, Nakatani T, Tomita S, Miura K.2018 J Pharmacol Sci. 136, 31-38.
doi: 10.1016/j.jphs.2017.12.004.

*2017 Hypertension Research Award of Excellent